ArticleFrontiers in neurology
Multi-centered reassessment of CRS-R in disorders of consciousness: a dimensionality reduction study from cognition and motor function.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to enhance the Coma Recovery Scale-Revised (CRS-R) for disorders of consciousness (DoC) by developing a two-dimensional model differentiating cognition and motor function. Methods: We analyzed 124 DoC patients retrospectively and validated findings using five multicenter datasets ( Results: The model achieved high accuracy (0.94), precision (0.92), and recall (0.99). Patients with minimally conscious state (MCS) or emerged MCS showed significantly higher scores than vegetative state (VS) patients ( Conclusions: The two-dimensionally reduced representation of CRS-R scores maintains diagnostic accuracy while improving DoC classification. The four-quadrant model enables personalized interventions. Trial registration: Our study has been verified by the Chinese Clinical Trial Registry with the registration number: ChiCTR2400085855, and the registration date is June 19, 2024.
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