Evidence map›Paper›PMID 41929554›Full record

ArticleInternational cancer conference journal2026

Pembrolizumab for high TMB castration-resistant prostate cancer: A precision medicine case report.

Vincenzo Terrano, Erica Perri, Chiara Cioffo, Giusi Mastroianni, Maria Antonina Palumbo, Fortunato Ciardiello, Teresa Troiani, Stefania Napolitano

Abstract read
In one paragraph

Article in International cancer conference journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vincenzo TerranoDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Erica PerriDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Chiara CioffoDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Giusi MastroianniDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Maria Antonina PalumboDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Fortunato CiardielloDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Teresa TroianiDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Stefania NapolitanoDepartment of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0003-3504-8349

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report describes the clinical management of a 68-year-old man with concurrent invasive melanoma and metastatic castration-resistant prostate cancer (mCRPC). Initially diagnosed with BRAF V600E-mutated melanoma, he received Dabrafenib and Trametinib. Later, prostate cancer was diagnosed with bilateral pulmonary metastases. Despite initial treatment with Triptorelin, Docetaxel, and Abiraterone, disease progression occurred. A liquid biopsy revealed an extremely high Tumor Mutational Burden (TMB) and mutations including

Indexed as

ImmunotherapyMetastatic castration-resistant prostate cancer (mCRPC)PembrolizumabTumor mutational burden (TMB)

Identifiers

PMID41929554
PMCPMC13038841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.