ArticleExperimental and therapeutic medicine2026
Deciphering the dynamics of the splenium: A comprehensive analysis of flair hyperintensity variations.
Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The splenium of the corpus callosum plays a pivotal role in interhemispheric communication and undergoes various changes with ageing. The present study aimed to elucidate the age-related variations in splenial fluid-attenuated inversion recovery (FLAIR) hyperintensity, providing insights into the normal ageing process of the brain and enhancing the clinical interpretation of magnetic resonance (MR) imaging. In the present retrospective cohort study, cerebral MR imaging of 1,176 patients was analysed following application of strict inclusion and exclusion criteria to isolate age and sex-related changes and other factors that can affect splenium hyperintensity. The present study focused on measuring the thickness (anteroposterior) of splenial FLAIR hyperintensity, with interobserver agreement assessed to ensure measurement reliability. Statistical analyses, including the Mann-Whitney U test for sex comparisons and the Kruskal-Wallis test for age group comparisons, were employed to investigate the effects of age, sex, radiation therapy and Fazekas score on splenial FLAIR hyperintensity. The present study demonstrated a significant increase in the presence of splenial FLAIR hyperintensity and thickness (P<0.001; P=0.006) with advancing age, particularly in individuals >57 years of age. No significant differences were observed between male and female participants, suggesting that these age-related changes were consistent across sex. Splenium hyperintensity thickness was significantly higher in the group that received radiation therapy and in the patient group with a Fazekas score of 3 (0.048, 0.018). Interobserver agreement was evaluated using the intraclass correlation coefficient (ICC) to assess measurement consistency (ICC=0.977; P<0.001). The present study provides crucial insights into the age-related dynamics of the splenium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.