Evidence map›Paper›PMID 41929533›Full record

ArticleExperimental and therapeutic medicine2026

Maresin 1 activates autophagy through SIRT1/PPAR-γ signaling to mitigate high glucose-induced pyroptosis in human retinal pigment epithelial cells.

Jun Zhang, Ding Zhao, Yuanqing Zhang, Haoxiang Sun, Zhipeng Yan, Haiyan Sun

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun ZhangDepartment of Ophthalmology and Ophthalmic Diseases, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Ding ZhaoDepartment of Ophthalmology and Ophthalmic Diseases, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Yuanqing ZhangDepartment of Ophthalmology and Ophthalmic Diseases, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Haoxiang SunDepartment of Ophthalmology and Ophthalmic Diseases, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Zhipeng YanDepartment of Ophthalmology and Ophthalmic Diseases, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.
Haiyan SunDepartment of Ophthalmology and Ophthalmic Diseases, Hebei Medical University Third Hospital, Shijiazhuang, Hebei 050051, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence suggests that maresin 1 (MaR1), a docosahexaenoic acid-derived specialized pro-resolving lipid mediator, safeguards ARPE-19 cells against high glucose (HG)-induced ferroptosis, with potential relevance in preventing the onset and progression of diabetic retinopathy (DR). Building upon this observation, the present study aimed to elaborate on the functional role of MaR1 in DR and explore the underlying mechanisms mediating its protective effects. ARPE-19 cells were exposed to HG to mimic DR

Indexed as

ARPE-19 cellsautophagyhigh glucosemaresin 1pyroptosissirtuin 1/peroxisome proliferator-activated receptor-γsignaling

Identifiers

PMID41929533
PMCPMC13040335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.