ArticleExperimental and therapeutic medicine2026
Immunohistochemical evaluation of gastric-type markers in primary extramammary Paget disease: Differential MUC5AC expression between
Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primary extramammary Paget disease (EMPD) is a rare cutaneous adenocarcinoma characterised by intraepithelial proliferation of mucin-containing carcinoma cells, with invasive carcinoma occasionally present. A characteristic immunohistochemical feature of primary EMPD is expression of MUC5AC, a gastric-type mucin core protein; however, the expression of MUC5AC in invasive EMPD remains controversial. Furthermore, the expression of other gastric-type markers, including hepatocyte nuclear factor 4α (HNF4α) and claudin 18, has not been fully investigated in primary EMPD. The present study aimed to clarify the expression profiles of MUC5AC in both
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