Evidence map›Paper›PMID 41929526›Full record

ArticleOpen journal of immunology2011

Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin.

Kazue Takahashi, Wei-Chuan Chang, Patience Moyo, Mitchell R White, Parool Meelu, Anamika Verma, Gregory L Stahl, Kevan L Hartshorn, Vijay Yajnik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open journal of immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kazue TakahashiProgram of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Wei-Chuan ChangProgram of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Patience MoyoProgram of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Mitchell R WhiteDepartment of Medicine, Boston University School of Medicine, Boston, USA.
Parool MeeluGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Anamika VermaDepartment of Medicine, Boston University School of Medicine, Boston, USA.
Gregory L StahlCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Institute of Medicine, Harvard Medical School, Boston, USA.
Kevan L HartshornDepartment of Medicine, Boston University School of Medicine, Boston, USA.
Vijay YajnikGastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Funding

Development of novel immunotherapy for influenza virus infectionU01AI074503 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI TAKAHASHI, KAZUE · 2007 to 2011
$4.7M
Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic CellsR21AI077081 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI TAKAHASHI, KAZUE · 2007 to 2008
$475k
NIAID NIH HHS R21 AI077081NIAID NIH HHS U01 AI074503
6 · The paper itself

Abstract

Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbohydrates that are exposed on pathogens. In this study, we observed that fructose down regulates MBL-mediated innate immune mechanisms against both influenza A Virus (IAV) and

Indexed as

CoagulationComplementFructoseInfluenza A VirusMannose-Binding LectinStaphylococcus Aureus

Identifiers

PMID41929526
PMCPMC13042316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.