ArticleFrontiers in cellular and infection microbiology2026
Unilateral biportal endoscopic debridement with antibiotic-loaded cement beads implantation for lumbar spinal infection: a preliminary report on feasibility and early clinical outcomes.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Direct pedicle screw fixation in infected vertebrae for acute pyogenic spondylitis: short-term outcomes from a single-arm retrospective study.Frontiers in cellular and infection microbiology · 2026Article
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8 authors.
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Abstract
Objective: A preliminary evaluate was conducted on the feasibility and clinical efficacy of unilateral biportal endoscopic (UBE) debridement combined with intervertebral antibiotic-loaded cement beads (ALCBs) implantation for lumbar spinal infection. Methods: We retrospectively analyzed 12 patients with lumbar spinal infections who underwent the procedure between March 2021 and June 2024. Surgical details and complications were documented. Clinical outcomes were evaluated using VAS for pain, ODI, ASIA impairment scale, inflammatory markers, and radiographic parameters, which were measured at multiple timepoints before and after surgery. Results: All 12 patients successfully underwent the procedure. The mean operative time was 85.58 ± 13.15 minutes, with an estimated blood loss of 51.83 ± 11.50 mL and a mean hospital stay of 6.50 ± 1.45 days. The average follow-up period was 16.50 ± 4.20 months. Significant improvements were observed in all clinical and laboratory outcomes (all overall P< 0.05). Back pain VAS decreased from 6.50 ± 1.17 preoperatively to 2.50 ± 1.72 at final follow-up; ODI improved from 67.42 ± 2.27 to 19.17 ± 3.76. Inflammatory markers also showed significant reductions: WBC (13.47 ± 4.12 to 8.17 ± 0.85 ×10 Conclusion: This preliminary study suggests that for carefully selected patients with lumbar spinal infections, the combined UBE debridement and ALCB implantation technique may represent a feasible and promising minimally invasive option, offering thorough debridement, sustained local antibiotic delivery, and mechanical support. These initial findings, based on a small single-center series, warrant validation through prospective comparative trials.
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