ArticleFrontiers in cellular and infection microbiology2026
Association of the blood urea nitrogen to serum albumin ratio on prognosis in patients with bacterial meningitis: a retrospective cohort study.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Early identification of high-risk patients is crucial for improving outcomes of bacterial meningitis (BM) patients. The blood urea nitrogen to albumin (BUN/ALB) ratio has demonstrated prognostic value in various critical illnesses, but its role in BM remains unestablished. Methods: This retrospective cohort study included 146 adult patients with microbiologically confirmed BM hospitalized between 2010 and 2025. BUN/ALB ratio within 6 hours of admission was calculated. Based on 3-month post-discharge modified Rankin Scale (mRS) scores, patients were dichotomized into favorable (mRS 0-2) and unfavorable (mRS 3-6) prognostic groups. Multivariable logistic regression was used to examine the association between BUN/ALB ratio and unfavorable outcome, adjusting for relevant confounders. The predictive performance was assessed using receiver operating characteristic curve analysis. Results: Among included patients, 87 (59.6%) had unfavorable outcomes. The unfavorable prognosis group exhibited significantly higher admission BUN/ALB ratios compared to the favorable group (5.23 vs. 2.86, Conclusion: Admission BUN/ALB ratio independently predicts 3-month unfavorable neurological outcomes in BM patients. This routinely available, low-cost biomarker may serve as a practical tool for early risk stratification and could guide more intensive monitoring and intervention in high-risk patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.