ReviewFrontiers in bioengineering and biotechnology2026
Resistance mechanisms of bacterial biofilms on orthopedic implants and research progress on novel anti-biofilm coatings.
Review in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
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Authors and funding
7 authors.
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Abstract
Implant-associated infections (IAIs) have become a major challenge in clinical orthopedics due to the formation of bacterial biofilms and their complex resistance mechanisms. This review systematically summarizes the resistance mechanisms of bacterial biofilms on the surface of orthopedic implants and critically analyzes the research progress of novel anti-biofilm coatings. Novel antibiofilm coating strategies have shown a diversified development, which are mainly classified into: antimicrobial drug-releasing strategies, surface physicochemical modification strategies, nanotechnology-based antimicrobial strategies, and emerging bioactive strategies. Studies have shown that it is difficult to balance long-lasting antimicrobial activity and biocompatibility with a single strategy, and there is a need to develop multi-mechanism synergistic coatings (e.g., anti-adhesion, contact-killing, immune-modulatory) and to optimize the coating design by combining with artificial intelligence. Despite the potential of nanotechnology and bioactive strategies, their biosafety assessment, scale-up and long-term
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