Evidence map›Paper›PMID 41929416›Full record

ReviewJournal of anesthesia and translational medicine2024

The regulatory role of dexmedetomidine in NLRP3 inflammasome-related organ protection.

Xiang Wang, Xiang Chen, E Wang, Hui Luo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of anesthesia and translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiang WangDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.
Xiang ChenDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.
E WangDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.
Hui LuoDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ protection is paramount during the perioperative period. Dexmedetomidine, a commonly used anesthetic, has gained attention for its potential anti-inflammatory and organ-protective properties. The NLRP3 inflammasome, a key inflammatory signaling molecule, contributes to organ dysfunction. This review examines recent research investigating dexmedetomidine's ability to protect organs by inhibiting NLRP3 inflammasome activation. A deeper understanding of these mechanisms could lead to novel therapeutic strategies for improving patient outcomes.

Indexed as

DexmedetomidineNLRP3 inflammasomeOrgan protectionPyroptosis

Identifiers

PMID41929416
PMCPMC13001778

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.