Open lung ventilation with low tidal volumes, staircase recruitment maneuvers, high PEEP and decremental PEEP titration vs ARDSNet in ARDS: A systematic review and meta-analysis.

Siyao Zeng, Zhipeng Yao, Chunming Guan, Shanpeng Cui, Zhen Quan, Yue Li, Junbo Zheng, Hongliang Wang

Abstract readReview

In one paragraph

Review in Journal of anesthesia and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siyao ZengHarbin Medical University Graduate School, Harbin Medical University, Harbin 150000, China.

Zhipeng YaoDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.

Chunming GuanHarbin Medical University Graduate School, Harbin Medical University, Harbin 150000, China.

Shanpeng CuiHarbin Medical University Graduate School, Harbin Medical University, Harbin 150000, China.

Zhen QuanHarbin Medical University Graduate School, Harbin Medical University, Harbin 150000, China.

Yue LiDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.

Junbo ZhengDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.

Hongliang WangDepartment of Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin 150000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of open lung ventilation (OLV) with low tidal volumes (TV), staircase recruitment maneuvers (SRMs), high positive end-expiratory pressure (PEEP), and decremental PEEP titration on acute respiratory distress syndrome (ARDS) patients is still uncertain. We aim to assess the impact of this OLV versus ARDS Network (ARDSNet) on patients with ARDS. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs). PubMed, Scopus, Web of Science, Embase, and Cochrane were searched from inception through August 11, 2025. Statistical analysis used risk ratios (RR), weighted mean differences (WMD), and 95 % confidence intervals (95 % CI). Based on seven RCTs involving 1545 participants, it was found that for ARDS patients whose lung recruitability has not been assessed, compared to ARDSNet, OLV does not reduce hospital mortality (RR: 1.03; 95 % CI: 0.94 to 1.13;

Indexed as

Acute respiratory distress syndromeARDS NetworkOpen lung ventilationPositive end-expiratory pressureRecruitment maneuvers

Identifiers

PMID41929372

DOI10.1016/j.jatmed.2025.08.001

PMCPMC13001771

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