Evidence map›Paper›PMID 41929286›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Human Genetic Analysis Reveals Circulating Alpha-1 Antitrypsin Level as a Protective Factor in Sepsis.

Dandan Tan, Ping Zhang, Thomas M Zheng, Kevin Y H Liang, Chen-Yang Su, Yiheng Chen, Tianyuan Lu, J Brent Richards, Amanda Y Chong, Patrick R Lawler and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dandan TanLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Ping ZhangCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0001-7063-7769
Thomas M ZhengLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.ORCID 0009-0005-9674-5991
Kevin Y H LiangLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Chen-Yang SuVictor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montréal, Québec, Canada.ORCID 0000-0001-6071-4660
Yiheng ChenMultiomic Science, Queen Mary University of London, UK.
Tianyuan LuCenter for Precision Medicine, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-5664-5698
J Brent RichardsLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Amanda Y ChongCentre for Human Genetics, University of Oxford, Oxford, UK.
Patrick R LawlerDivision of Cardiology, McGill University Health Centre, Montréal, Québec, Canada.
Fergus HamiltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Infection Sciences, North Bristol NHS Trust, Bristol, UK.
Alexander J MentzerCentre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0002-4502-2209
Julian C KnightCentre for Human Genetics, University of Oxford, Oxford, UK.
Guillaume Butler-LaporteLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.ORCID 0000-0001-5388-0396

Funding

Advancing statistical genetics tools for reliable drug target discovery and treatment optimizationR35GM162188 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Tianyuan Lu · 2026 to 2026
$414k
NIGMS NIH HHS R35 GM162188Wellcome Trust
6 · The paper itself

Abstract

Sepsis is a dysregulated host response to infection and a leading cause of global mortality, yet effective targeted therapies remain lacking. Here, we applied a proteogenomic framework integrating large-scale human genetics with circulating proteomics to identify therapeutic targets. In a meta-analysis of genome-wide association studies of 60,314 sepsis cases and 1,464,733 controls, we identified four genome-wide significant loci, including a missense variant in

Identifiers

PMID41929286
PMCPMC13042101

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.