Evidence map›Paper›PMID 41929284›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Ancestry-specific effects of

Ana I Boeriu, Tianjie Gu, Brian Fullton-Howard, Esteban M Lucero, Jonathan Shortt, Chris Gignoux, Farid Rajabli, Anthony J Griswold, Kristine Yaffe, Shea J Andrews

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana I BoeriuDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.ORCID 0009-0000-5469-4085
Tianjie GuJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, US.
Brian Fullton-HowardDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Esteban M LuceroDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jonathan ShorttDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Chris GignouxDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Farid RajabliJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, US.
Anthony J GriswoldJohn P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, US.ORCID 0000-0003-1925-7810
Kristine YaffeDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Shea J AndrewsDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.ORCID 0000-0002-1921-9470

Funding

APOE in the Predisposition to, Protection from and Prevention of Alzheimer's DiseaseR01AG069453 · NIA · BANNER HEALTH · PI ASHTON, NICHOLAS, LANGBAUM, JESSICA BROOKE · 2020 to 2025
$27.4M
Understanding the role of genetic admixture on Alzheimer’s Disease risk in Latíno PopulationsK00AG080847 · NIA · UNIVERSITY OF COLORADO DENVER · PI LUCERO, ESTEBAN M · 2022 to 2025
$361k
NIA NIH HHS K00 AG080847NIA NIH HHS R01 AG069453
6 · The paper itself

Abstract

Importance: Objective: To determine whether genetic ancestry modulates Design Setting Participants: Cross-sectional analysis of community-dwelling older adults from the Health and Aging Brain Study-Health Disparities (HABS-HD) cohort (N = 2733). Participants spanning the cognitive spectrum underwent cognitive assessment, neuroimaging, plasma biomarker collection, and genome-wide genotyping from 2018 to 2023. Main Outcomes and Measures: Cognitive performance (global cognition, memory, executive function, verbal ability), brain morphometry (cortical thickness, hippocampal volume), and plasma biomarkers (Aβ Results: In the full cohort, Conclusions and Relevance: Genetic ancestry modifies the effect of

Identifiers

PMID41929284
PMCPMC13042099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.