ArticleJournal of anesthesia and translational medicine2025
Anesthetic management of delayed malignant hyperthermia during scheduled right frontotemporal craniotomy.
Article in Journal of anesthesia and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Malignant hyperthermia is a critical complication that arises when certain anesthetics are administered to susceptible patients, posing a significant risk of mortality if not promptly identified and treated. Case presentation: We present a case of a 48-year-old male admitted for the excision of an intracranial tumor. The patient underwent orotracheal intubation under total intravenous anesthesia and non-depolarizing muscle relaxants. After intubation, anesthetic maintenance was achieved through the administration of sevoflurane and intravenous agents. During the initial stage, there was a gradual increase in the patient's heart rate and end-tidal carbon dioxide pressure (PetCO Conclusions: This case report details the diagnosis and management of a 48-year-old male patient with a homozygous RYR1 gene mutation who developed delayed malignant hyperthermia (MH) following sevoflurane anesthesia. Despite the absence of the specific antagonist dantrolene, the condition was successfully controlled through active symptomatic management. Postoperative genetic testing further confirmed that both the patient and his son carried the pathogenic RYR1 mutation, definitively establishing their MH susceptibility.
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