Evidence map›Paper›PMID 41929248›Full record

ArticleFrontiers in pharmacology2026

Indoleamine 2,3-dioxygenase-regulated macrophages metabolic reprogramming rescues tacrolimus-induced nephrotoxicity.

Menghan Ye, Rui Zhang, Pengpeng Guo, Jinping Zhou, Dianwen Yu, Tianze Shang, Peixia Li, Jiaxin Li, Kaiyu Liu, Yani Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Menghan Ye *Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Rui Zhang *Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Pengpeng GuoWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jinping ZhouWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dianwen YuWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tianze ShangWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Peixia LiWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiaxin LiWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kaiyu LiuWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yani LiuWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Shaojun ShiWuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophage metabolic reprogramming toward the M1 phenotype is a key pathological feature of kidney injury. Recent studies have increasingly highlighted the importance of

Indexed as

fatty acid oxidationIDO1macrophage polarizationmetabolic reprogrammingtacrolimus

Identifiers

PMID41929248
PMCPMC13038910

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.