Evidence map›Paper›PMID 41929244›Full record

ArticleFrontiers in pharmacology2026

MG53 protects against intestinal inflammation by inhibiting NLRP3 inflammasome activation.

Zhongguang Li, Zachary D Dawson, XiangGuang Li, Serenali Zhao, Mattew Bu, Fei Jiang, Yuchen Chen, Min Zhang, Xindi Zeng, Ki Ho Park and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Zhongguang LiDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Zachary D DawsonDivision of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, United States.
XiangGuang LiDepartment of Surgery, The Ohio State University, Columbus, OH, United States.
Serenali ZhaoDepartment of Surgery, The Ohio State University, Columbus, OH, United States.
Mattew BuDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Fei JiangDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Yuchen ChenDivision of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, United States.
Min ZhangDepartment of Internal Medicine, The Ohio State University, Columbus, OH, United States.
Xindi ZengDivision of Surgical Sciences, Department of Surgery, University of Virginia, Charlottesville, VA, United States.
Ki Ho ParkDepartment of Surgery, The Ohio State University, Columbus, OH, United States.
Jing LuDepartment of Surgery, The Ohio State University, Columbus, OH, United States.
Jinshan HeDepartment of Surgery, The Ohio State University, Columbus, OH, United States.
KyungEun LeeDepartment of Surgery, The Ohio State University, Columbus, OH, United States.
Prosper N BoyakaDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Haichang LiDepartment of Veterinary Biosciences, The Ohio State University, Columbus, OH, United States.
Jianjie MaDepartment of Surgery, The Ohio State University, Columbus, OH, United States.

Funding

Mitigating neuroinflammation and enhancing neuronal integrity in Alzheimer's diseaseR01AG072430 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma · 2022 to 2026
$3.4M
MG53 function in muscle agingR01AG071676 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma, Ki Ho Park · 2022 to 2026
$3.1M
NIA NIH HHS R01 AG071676NIA NIH HHS R01 AG072430
6 · The paper itself

Abstract

Background and Objectives: Inflammatory bowel disease (IBD) involves dysregulated immune responses and chronic intestinal inflammation. The nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome plays a critical role in IBD pathogenesis, but regulatory mechanisms remain not fully understood. Mitsugumin 53 (MG53, also known as TRIM72), originally identified as a critical membrane repair protein, has emerged as a novel regulator of inflammatory processes. To investigate the protective role of MG53 in colitis and elucidate its mechanisms in regulating NLRP3 inflammasome activation in IBD. Methods: We used dextran sodium sulfate (DSS)-induced colitis models comparing Results: Conclusion: MG53 is a physiological regulator of NLRP3 inflammasome activation that protects against colitis, suggesting therapeutic potential for IBD.

Indexed as

dextran sodium sulfateinflammasome activationinflammatory bowel diseaseMG53NLRP3

Identifiers

PMID41929244
PMCPMC13039094

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.