Evidence map›Paper›PMID 41929172›Full record

ArticlebioRxiv : the preprint server for biology2026

Hydrogel-Embedded Precision-Cut Lung Slices Recapitulate Fibrotic Gene Expression and Enable Therapeutic Response Evaluation.

Alicia E Tanneberger, Rachel Blomberg, Tvishi Yendamuri, Haley Noelle, Jeffrey G Jacot, Janette K Burgess, Chelsea M Magin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alicia E TannebergerDepartment of Biomedical Engineering, University of Colorado, Denver | Anschutz, Aurora, CO, USA.
Rachel BlombergDepartment of Biomedical Engineering, University of Colorado, Denver | Anschutz, Aurora, CO, USA.
Tvishi YendamuriDepartment of Biomedical Engineering, University of Colorado, Denver | Anschutz, Aurora, CO, USA.
Haley NoelleDepartment of Biomedical Engineering, University of Colorado, Denver | Anschutz, Aurora, CO, USA.
Jeffrey G JacotDepartment of Biomedical Engineering, University of Colorado, Denver | Anschutz, Aurora, CO, USA.
Janette K BurgessUniversity of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands.
Chelsea M MaginDepartment of Biomedical Engineering, University of Colorado, Denver | Anschutz, Aurora, CO, USA.

Funding

Colorado Clinical and Translational Sciences Institute (CCTSI)UM1TR004399 · NCATS · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS, RONALD J. SOKOL · 2023 to 2026
$30.7M
Cardiovascular Biomechanics and Imaging in Down SyndromeT32HL072738 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI SHANDAS, ROBIN · 2003 to 2025
$4.9M
Hybrid Hydrogel Biomaterials Comprising Clickable Decellularized Extracellular Matrix for Engineering Dynamic 3D Models of FibrosisR01HL153096 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MAGIN, CHELSEA M · 2020 to 2024
$2.6M
CTSA Predoctoral T32 at University of Colorado DenverT32TR004367 · NCATS · UNIVERSITY OF COLORADO DENVER · PI Lisa Cicutto · 2023 to 2026
$1.5M
NCATS NIH HHS T32 TR004367NCATS NIH HHS UM1 TR004399NHLBI NIH HHS R01 HL153096NHLBI NIH HHS T32 HL072738
6 · The paper itself

Abstract

Precision-cut lung slices (PCLS) retain the native cells and extracellular matrix that contribute to the structural and functional integrity of lung tissue. This technique enables the study of cell-matrix interactions and is particularly useful for pre-clinical pharmacological studies. More specifically, PCLS are widely used to model the complex pathophysiology of pulmonary fibrosis, an uncurable and progressive interstitial lung disease. Current

Indexed as

biomaterialsex vivo disease modelinghydrogelnew approach methodologyPrecision-cut lung slices (PCLS)pulmonary fibrosistissue engineering

Identifiers

PMID41929172
PMCPMC13041946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.