Evidence map›Paper›PMID 41929167›Full record

ArticlebioRxiv : the preprint server for biology2026

Riluzole treatment paradoxically increases motoneuron excitability in ALS due to hyperactive homeostasis.

Amr A Mahrous, Bradley S Heit, C J Heckman

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amr A MahrousDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, 60611.ORCID 0000-0001-9027-1960
Bradley S HeitDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, 60611.ORCID 0000-0002-4821-5225
C J HeckmanDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA, 60611.ORCID 0000-0002-1324-7278

Funding

Motoneuron mortality in neurodegenerative diseases induced by homeostatic dysregulation of excitabilityR01NS110953 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BINDER, MARC D, HECKMAN, CHARLES · 2019 to 2023
$2.8M
NINDS NIH HHS R01 NS110953
6 · The paper itself

Abstract

Riluzole is the most commonly prescribed among the limited approved therapies for amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by progressive motoneuron loss and paralysis. It is thought to act by suppressing motoneuron excitability and glutamate release, but its clinical benefits are modest and often diminish over time. We previously showed that homeostatic mechanisms in the SOD1

Indexed as

Amyotrophic Lateral Sclerosis (ALS)Hypervigilant HomeostasisMotoneuron ExcitabilityRiluzole

Identifiers

PMID41929167
PMCPMC13042003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.