Evidence map›Paper›PMID 41929146›Full record

ArticlebioRxiv : the preprint server for biology2026

Lymphatic Endothelial Cells Regulate Neutrophil Phenotypes and Function in a Microphysiological Model of Infection.

Kelsea A Sholty, Sheena C Kerr, David J Beebe

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kelsea A SholtyDepartment of Comparative Biomedical Sciences, University of Wisconsin-Madison, Madison, 53706, USA.ORCID 0000-0002-6162-4920
Sheena C KerrCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, 53705, USA.
David J BeebeCarbone Cancer Center, School of Medicine and Public Health, University of Wisconsin-Madison, 53705, USA.ORCID 0000-0002-0415-9006

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Comparative Biomedical Sciences Training ProgramT32OD010423 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Marulasiddappa Suresh · 2012 to 2026
$5.0M
Under-oil open microfluidic system (UOMS) for studying systemic fungal infectionR01AI154940 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BEEBE, DAVID J, MCCLEAN, MEGAN N · 2021 to 2025
$3.8M
Development of a human intestinal microphysiological system for the study of immune responses to protozoan parasitesR01AI172874 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI David J Beebe, LAURA J KNOLL · 2023 to 2026
$3.1M
NCI NIH HHS P30 CA014520NIAID NIH HHS R01 AI154940NIAID NIH HHS R01 AI172874NIH HHS T32 OD010423
6 · The paper itself

Abstract

Early skin inflammation requires coordinated immune regulation, with neutrophils acting as first-line responders. While the blood vasculature and its role in neutrophil recruitment during infection has been extensively studied, the lymphatic system remains comparatively understudied despite its known role in immune cell trafficking. Growing evidence suggests lymphatic vessels actively participate in regulating inflammatory responses, yet whether they coordinate neutrophil behavior during skin infection remains unclear.

Identifiers

PMID41929146
PMCPMC13041953

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.