ArticlebioRxiv : the preprint server for biology2026
Iron toxicity potentiates cell-type specific amyloid beta proteotoxicity in
Wilson Peng, Kaitlin B Chung, Ali Al-Qazzaz, Aidan Straut, M Kerry O'Banion, B Paige Lawrence, Robert T Dirksen, John O Onukwufor
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Wilson PengDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.
Kaitlin B ChungDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.
Ali Al-QazzazDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.
Aidan StrautDepartment of Environmental Medicine and Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.
M Kerry O'BanionDepartment of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.ORCID 0000-0003-1246-3363 B Paige LawrenceDepartment of Environmental Medicine and Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.
Robert T DirksenDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.
John O OnukwuforDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester NY, 14642 USA.ORCID 0000-0003-4776-5003 Funding
VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Martha Susiarjo · 1985 to 2026
$42.8MTraining in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MMitochondrial ROS Microdomains and Neuronal IschemiaR01NS092558 · NINDS · UNIVERSITY OF ROCHESTER · PI WOJTOVICH, ANDREW PHILLIP · 2015 to 2025
$3.7MT32 University of Rochester Aging and Alzheimer's disease Training ProgramT32AG076455 · NIA · UNIVERSITY OF ROCHESTER · PI M. KERRY O'BANION · 2022 to 2026
$1.5MNIA NIH HHS T32 AG076455NIEHS NIH HHS P30 ES001247NIEHS NIH HHS T32 ES007026NIH HHS P40 OD010440NINDS NIH HHS R01 NS092558
6 · The paper itselfAbstract
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by memory loss and a decline in cognitive function. Hallmarks of AD include an age-dependent accumulation of toxic amyloid beta (Aβ) 42 in the brain, energy dyshomeostasis caused by mitochondrial dysfunction, and iron overload. However, the role of iron overload and mitochondrial dysfunction in AD pathology is unknown and their precise relationship with Aβ 42 toxicity in AD pathology is unclear.
Indexed as
Iron BurdenIron SensitivityMitochondrial DysfunctionTemperatureTissue-specific Aβ 42 Toxicity
Identifiers
PMID41929143
PMCPMC13042036
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