Evidence map›Paper›PMID 41929094›Full record

ArticlebioRxiv : the preprint server for biology2026

Sex-specific differences in endocannabinoid regulation of cocaine-evoked dopamine in the medial nucleus accumbens shell.

Andrew D Gaulden, Kristin Chase, Jayme R McReynolds

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Andrew D GauldenDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, 2120 E. Galbraith Rd. Cincinnati, OH 45237 USA.
Kristin ChaseDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, 2120 E. Galbraith Rd. Cincinnati, OH 45237 USA.
Jayme R McReynoldsDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, 2120 E. Galbraith Rd. Cincinnati, OH 45237 USA.ORCID 0000-0002-4398-8691

Funding

Role of prelimbic cortical endocannabinoid signaling in enhanced cocaine-seeking behavior following combined repeated stress and cocaine use in ratsR37DA057944 · NIDA · UNIVERSITY OF CINCINNATI · PI Jayme Rose McReynolds · 2024 to 2026
$1.2M
Recruitment of endocannabinoid signaling in the ventral tegmental area and stress-induced escalation of cocaine intakeK01DA045295 · NIDA · UNIVERSITY OF CINCINNATI · PI MCREYNOLDS, JAYME ROSE · 2018 to 2020
$409k
Endocannabinoid regulation of the corticoaccumbens pathway and stress-enhanced cocaine-seeking behaviorF31DA059206 · NIDA · UNIVERSITY OF CINCINNATI · PI GAULDEN, ANDREW · 2023 to 2024
$91k
NIDA NIH HHS F31 DA059206NIDA NIH HHS K01 DA045295NIDA NIH HHS R37 DA057944
6 · The paper itself

Abstract

Endocannabinoid (eCB) signaling is a key regulator of reward-related dopaminergic signaling, particularly in response to drugs of abuse, such as cocaine. To date, our understanding of this mechanism has primarily been limited to male subjects. Prior work establishes that female cocaine users have more adverse outcomes, and female rats show greater sensitivity to cannabinoid type 1 receptor (CB1R) regulation of cocaine self-administration. Therefore, we hypothesize that female rats exhibit enhanced eCB regulation of cocaine-evoked dopamine (DA). We used

Indexed as

cocainedopamineendocannabinoidnucleus accumbenssex differences

Identifiers

PMID41929094
PMCPMC13041950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.