Evidence map›Paper›PMID 41929046›Full record

ArticlebioRxiv : the preprint server for biology2026

Validated CRISPR/Cas9 guide RNAs targeting neurodevelopmental genes in the tunicate

Sydney Popsuj, Tenzin Kalsang, Kwantae Kim, Erica Drummond, Pooja Manekar, Pranavvarma Munagapati, Manasi Oleti, Hiroki Sato, Izabella Vickery, Eduardo D Gigante and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Sydney PopsujSwarthmore College, Swarthmore, PA, USA.
Tenzin KalsangGeorgia Institute of Technology, Atlanta, GA, USA.
Kwantae KimGeorgia Institute of Technology, Atlanta, GA, USA.
Erica DrummondGeorgia Institute of Technology, Atlanta, GA, USA.
Pooja ManekarGeorgia Institute of Technology, Atlanta, GA, USA.
Pranavvarma MunagapatiGeorgia Institute of Technology, Atlanta, GA, USA.
Manasi OletiGeorgia Institute of Technology, Atlanta, GA, USA.
Hiroki SatoGeorgia Institute of Technology, Atlanta, GA, USA.
Izabella VickeryGeorgia Institute of Technology, Atlanta, GA, USA.
Eduardo D GiganteKennesaw State University, Kennesaw, GA, USA.
Alberto StolfiGeorgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0001-7179-9700

Funding

Regulation of neurodevelopmental cell behaviors in CionaR01HD104825 · NICHD · GEORGIA INSTITUTE OF TECHNOLOGY · PI Christina Donata Cota, Alberto Stolfi · 2022 to 2026
$1.6M
Leveraging the biphasic life cycle of a non-vertebrate chordate to investigate developmental transitions and phenotypic plasticityR35GM158421 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Alberto Stolfi · 2025 to 2026
$772k
NICHD NIH HHS R01 HD104825NIGMS NIH HHS R35 GM158421
6 · The paper itself

Abstract

The development of the central nervous system (CNS) depends on tightly regulated gene expression programs that guide neural progenitor differentiation and neuronal subtype specification. The tunicate

Identifiers

PMID41929046
PMCPMC13042035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.