Evidence map›Paper›PMID 41929039›Full record

ArticlebioRxiv : the preprint server for biology2026

Topological Entanglement in Intrinsically Disordered Proteins: Sequence, Structural, and Functional Determinants.

Wangfei Yang, Henry Silvernail, Debasis Saha, Eleni Panagiotou, Wenwei Zheng

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wangfei YangCollege of Integrative Sciences and Arts, Arizona State University, Mesa, AZ 85212, USA.
Henry SilvernailBrophy College Preparatory, Phoenix, AZ 85012, USA.
Debasis SahaCollege of Integrative Sciences and Arts, Arizona State University, Mesa, AZ 85212, USA.
Eleni PanagiotouSchool of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ 85282, USA.
Wenwei ZhengCollege of Integrative Sciences and Arts, Arizona State University, Mesa, AZ 85212, USA.ORCID 0000-0002-9603-009X

Funding

Decoding the mechanism of disordered protein interactionsR35GM146814 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Wenwei Zheng · 2022 to 2026
$1.8M
DMS/NIGMS 1: Topological Dynamics Models of Protein FunctionR01GM152735 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PANAGIOTOU, ELENI · 2023 to 2025
$589k
NIGMS NIH HHS R01 GM152735NIGMS NIH HHS R35 GM146814
6 · The paper itself

Abstract

Intrinsically disordered proteins (IDPs) populate heterogeneous conformational ensembles that are difficult to characterize using conventional structural descriptors. As a result, it remains unclear which ensemble features meaningfully connect sequence composition to biological function. Here, we employ entanglement-based measures derived from knot theory to provide complementary insight into IDP organization. Using the human IDRome database, we analyze two continuous entanglement descriptors, the writhe and the second Vassiliev invariant

Identifiers

PMID41929039
PMCPMC13041981

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.