ArticlebioRxiv : the preprint server for biology2026
Quantitative imaging of schwannoma captures heterogeneity and accelerates preclinical testing, revealing distinct impacts of targeted therapies.
Emily A Wright, Jeremie Vitte, Sara I Veiga, Sarah E Bushnell, Catherine E Movsessian, Youwen Zhang, Jacquelyn Curtis, Ryan B Corcoran, Shannon L Stott, Marco Giovannini and 2 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Emily A WrightMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.
Jeremie VitteDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles, Los Angeles, CA 90095 USA.ORCID 0000-0002-2567-7988 Sara I VeigaCenter for Engineering in Medicine and BioMEMs Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129 USA.ORCID 0000-0002-9378-9148 Sarah E BushnellMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.
Catherine E MovsessianMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.
Youwen ZhangMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.
Jacquelyn CurtisMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.
Ryan B CorcoranMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.ORCID 0000-0001-8173-5778 Shannon L StottCenter for Engineering in Medicine and BioMEMs Resource Center, Surgical Services, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, MA 02129 USA.ORCID 0000-0002-0349-0522 Marco GiovanniniDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California, Los Angeles, Los Angeles, CA 90095 USA.ORCID 0000-0001-5183-8506 Christine Chiasson-MacKenzieMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.ORCID 0000-0002-4820-9765 Andrea I McClatcheyMassachusetts General Hospital Krantz Family Center for Cancer Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129 USA.ORCID 0000-0002-6150-3619 Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI Irene M. Ghobrial · 1985 to 2026
$330.6MNCI NIH HHS P30 CA006516
6 · The paper itselfAbstract
Schwannomas are debilitating hallmarks of familial schwannomatoses and common sporadic tumors that form on spinal and cranial nerves. Drug-based therapies for schwannoma are desperately needed but their development has been extremely slow and disappointing, impeded particularly by the poorly understood and surprisingly complex and heterogeneous biology of schwannomas, and by the inefficient use of physiologically relevant
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PMID41929036
PMCPMC13041863
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