Evidence map›Paper›PMID 41929025›Full record

ArticlebioRxiv : the preprint server for biology2026

Chiral methionine oxidation reagents reveal stereospecific proteome modifications.

Angel Gonzalez-Valero, Annika C S Page, Jayde M Bertoch, Fadi Alsarhan, Jaehee Kim, Amr A Alazali, Ritwik R Srinivas, Xiao Xie, Audrey G Reeves, Kacper Skakuj and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Angel Gonzalez-ValeroDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-4341-7546
Annika C S PageDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-5656-7848
Jayde M BertochDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3517-9309
Fadi AlsarhanDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-7605-1408
Jaehee KimDepartment of Chemistry, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-0812-488X
Amr A AlazaliDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley CA 94720, USA.
Ritwik R SrinivasDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley CA 94720, USA.ORCID 0009-0009-4325-344X
Xiao XieDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-9707-9461
Audrey G ReevesDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-9295-1222
Kacper SkakujDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-1563-0382
Theodore G CoffeyDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-9368-5269
Scott C VirgilDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0001-8586-5641
Jordan NafieBioTools Inc, West Palm Beach, FL 33407, USA.ORCID 0000-0003-1986-0302
Dan HeDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-9544-5672
Nam DaoDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0006-9543-6000
Amanda L GunawanDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0003-2133-8185
Rina DukorBioTools Inc, West Palm Beach, FL 33407, USA.ORCID 0000-0002-1981-3381
Andreas StahlDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-9096-3024
F Dean TosteDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-8018-2198
Christopher J ChangDepartment of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-5732-9497

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Methods for Selective Organic Synthesis based on Ionic CatalystsR35GM118190 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI F. Dean Toste · 2016 to 2026
$6.7M
Chemical Probes to Study Formaldehyde BiologyR01ES028096 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2017 to 2026
$4.1M
Chemical Probes to Study Methionine Redox BiologyR01GM139245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2020 to 2026
$2.9M
GPU Computing Cluster for Transformative Public Health driven Molecular ScienceS10OD034382 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI DURKIN, KATHLEEN A · 2023 to 2023
$491k
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NIEHS NIH HHS R01 ES028096NIGMS NIH HHS R01 GM079465NIGMS NIH HHS R01 GM139245NIGMS NIH HHS R35 GM118190NIGMS NIH HHS T32 GM066698NIH HHS S10 OD024998NIH HHS S10 OD034382
6 · The paper itself

Abstract

Life is predicated on chirality, a molecular asymmetry akin to the left and right versions of human hands. Here we show that privileged protein residues are predisposed for chiral regulation. We developed enantiomeric oxaziridine reagents that systematically identify pro-(

Identifiers

PMID41929025
PMCPMC13042024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.