ArticlebioRxiv : the preprint server for biology2026
Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation.
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Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
51 authors.
John Michael ReplogleNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-2735-8195
Jordan D MarksMedical Scientist Training Program, Mayo Clinic Alix School of Medicine, Rochester, MN 55905, USA.
Martin G FernandezDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2598-9682
Hebao YuanNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Dahyun YuNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Elizabeth WintersDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Vidhya Maheswari JawaharDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Rishi DeshmukhNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Renaldo SutantoLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Isabelle KowalCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Ashley FrankenfieldDepartment of Chemistry, George Washington University, Washington, DC 20052, USA.
Rachel ShiNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Yari CarlomagnoDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Karen Jansen-WestDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Tiffany W ToddDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Andrii KopachNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Iradukunda Sandra NdayambajeNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Yue A QiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Ananth ShantaramanCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.
Ignacio Pozo-CabanellDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Udit ShethDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Mei YueDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Duc DuongCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.
Shawn M FergusonDepartment of Cell Biology, Department of Neuroscience, Program in Cellular Neuroscience, Neurodegeneration and Repair, Wu Tsai Institute, Stephen & Denise Adams Center for Parkinson's Disease Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Markus DammeFaculty of Chemistry, Biochemistry I (BCI), University of Bielefeld, Bielefeld 33615, Germany.
Brad F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN 55902, USA.
Gregory S DayDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Benjamin KellmanRagon Institute of Mass General, MIT and Harvard, Cambridge, MA 02139, USA.
William C SkarnesThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN 55902, USA.
Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN 55902, USA.
Neill R Graff-RadfordDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Justin A McDonoughThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Mercedes PrudencioNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Sami J BarmadaDepartment of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Yongjie ZhangNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Ling HaoDepartment of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA.
Michael DeTureDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Bailey RawlinsonDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Erica Engelberg-CookDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Monica Castanedes CaseyDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Nathan PerezDepartments of Neuroscience and Neurology, Mayo Clinic, Jacksonville, FL 32224, USA.
Dennis W DicksonNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Aliza WingoDepartment of Psychiatry, University of California, Davis, Sacramento, CA 95817, USA.
Yue LiuDepartment of Neurology, University of California, Davis, Sacramento, CA 95817, USA.
Nicholas T SeyfriedCenter for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA.
Thomas S WingoDepartment of Neurology, University of California, Davis, Sacramento, CA 95817, USA.
Shyamal MosalagantiDepartment of Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.
Leonard PetrucelliNeuroscience Graduate Program, Mayo Graduate School, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
Michael E WardNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-5296-8051
Funding
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MResearch Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 2021 to 2026
$26.5MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MPathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6MAlzheimer variants: Propagation of shared functional changes across cellular networksU01AG072572 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JAGER, PHILIP L, ST GEORGE-HYSLOP, PETER HENRY · 2021 to 2025
$8.5MMSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7MThe brain multi-omic approach to identify key molecular drivers of neuropsychiatric symptoms in Alzheimer's dementiaR01AG072120 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Aliza Pham Wingo, Thomas Spurgeon Wingo · 2022 to 2026
$4.3MInvestigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLDR01NS132330 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Keith A Josephs, LEONARD PETRUCELLI · 2023 to 2026
$4.3MRNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degenerationR01NS097542 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARMADA, SAMI · 2016 to 2025
$3.8MIntegrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's DiseaseR01AG075827 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Aliza Pham Wingo, Thomas Spurgeon Wingo · 2022 to 2026
$3.7MBLRD VA I01 BX005686BLRD VA IK4 BX005219NIA NIH HHS F30 AG085984NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG072120NIA NIH HHS R01 AG075827NIA NIH HHS R01 AG079170NIA NIH HHS R01 AG085824NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG072572NIGMS NIH HHS DP2 GM150019NIGMS NIH HHS T32 GM141840NIGMS NIH HHS T32 GM145408NIH HHS S10 OD030275NINDS NIH HHS R01 NS097542NINDS NIH HHS R01 NS121608NINDS NIH HHS R01 NS132330NINDS NIH HHS R01 NS148028NINDS NIH HHS R35 NS137447NINDS NIH HHS R37 NS113943
Abstract
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