Evidence map›Paper›PMID 41928976›Full record

ArticlebioRxiv : the preprint server for biology2026

IDPForge: Deep Learning of Proteins with Global and Local Regions of Disorder.

Stefano DeCastro, Oufan Zhang, Zi Hao Liu, Julie D Forman-Kay, Teresa Head-Gordon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stefano DeCastroKenneth S. Pitzer Theory Center and Department of Chemistry, University of California, Berkeley, CA, USA.
Oufan ZhangKenneth S. Pitzer Theory Center and Department of Chemistry, University of California, Berkeley, CA, USA.
Zi Hao LiuMolecular Medicine Program, Hospital for Sick Children, Toronto, Ontario M5S 1A8, Canada.ORCID 0000-0002-8357-8507
Julie D Forman-KayMolecular Medicine Program, Hospital for Sick Children, Toronto, Ontario M5S 1A8, Canada.ORCID 0000-0001-8265-972X
Teresa Head-GordonKenneth S. Pitzer Theory Center and Department of Chemistry, University of California, Berkeley, CA, USA.ORCID 0000-0003-0025-8987

Funding

Calculating Ensembles of Discrete Dynamic Complexes and Condensed States of Intrinsically Disordered ProteinsR01GM127627 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Teresa L. Head-Gordon · 2018 to 2026
$2.1M
NIGMS NIH HHS R01 GM127627
6 · The paper itself

Abstract

Although machine learning has transformed protein structure prediction of folded protein ground states with remarkable accuracy, intrinsically disordered proteins and regions (IDPs/IDRs) are defined by diverse and dynamical structural ensembles that are predicted with low confidence by algorithms such as AlphaFold and RoseTTAFold. We present a new machine learning method, IDPForge (

Identifiers

PMID41928976
PMCPMC13041999

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.