Evidence map›Paper›PMID 41928961›Full record

ArticlebioRxiv : the preprint server for biology2026

Bile-mediated ToxS homodimerization provides a model for ToxRS periplasmic interactions.

Minje Kim, Deepak Balasubramanian, F Jon Kull, Salvador Almagro-Moreno, Charles R Midgett

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minje KimDepartment of Chemistry, Dartmouth College, Hanover, NH, USA.
Deepak BalasubramanianDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
F Jon KullDepartment of Chemistry, Dartmouth College, Hanover, NH, USA.ORCID 0000-0002-5191-3200
Salvador Almagro-MorenoDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA.
Charles R MidgettDepartment of Chemistry, Dartmouth College, Hanover, NH, USA.ORCID 0000-0001-9634-1165

Funding

Virulence gene regulators of enteric bacterial pathogens: Determining the structural and functional mechanisms of small molecule and polypeptide inhibitorsR01AI168157 · NIAID · DARTMOUTH COLLEGE · PI Fredrick Jon Kull, GEORGE Patrick MUNSON · 2023 to 2026
$2.5M
Structural regulation and response to bile salt induced stress of the Vibrio cholerae virulence factor ToxR and its binding partner ToxSR21AI140740 · NIAID · DARTMOUTH COLLEGE · PI KULL, FREDRICK JON · 2018 to 2019
$451k
NIAID NIH HHS R01 AI168157NIAID NIH HHS R21 AI140740
6 · The paper itself

Abstract

The ToxRS system belongs to a family of co-component transmembrane transcription regulators that act as sensors of environmental cues and regulate virulence gene expression in several bacterial pathogens. These systems are thought to operate by sensing environmental stimuli and transmitting signals through periplasmic domains to activate DNA-binding transcription factors. In the enteric pathogens

Identifiers

PMID41928961
PMCPMC13042144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.