Evidence map›Paper›PMID 41928956›Full record

ArticlebioRxiv : the preprint server for biology2026

Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.

Gu Xiao, George K Annor, Katherine W Harmon, Valery Chavez, Fayola Levine, Samuel Ahuno, Mohamed I Atmane, Samantha St Jean, Florencia P Madorsky Rowdo, Pamella Leybengrub and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Gu XiaoThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0000-0001-8433-9121
George K AnnorThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0000-0003-2598-1012
Katherine W HarmonThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0009-0006-3249-3198
Valery ChavezThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0000-0003-2962-0855
Fayola LevineThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.
Samuel AhunoThe Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021.
Mohamed I AtmaneThe Laboratory of Comparative Pathology (LCP), Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, NY, New York, NY 10021 USA.
Samantha St JeanThe Laboratory of Comparative Pathology (LCP), Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, NY, New York, NY 10021 USA.ORCID 0000-0001-5555-9299
Florencia P Madorsky RowdoEnglander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021.ORCID 0000-0002-8504-1690
Pamella LeybengrubThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0009-0009-5407-9109
AnnMarie GaglioThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0009-0006-0751-1083
Viola EllisonThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0000-0002-4275-5570
Divya VenkateshSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY10021.ORCID 0000-0003-4787-973X
Siyu SunThe Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021.ORCID 0000-0001-8461-9609
Taha MerghoubSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY10021.ORCID 0000-0002-1518-5111
Benjamin GreenbaumThe Halvorsen Center for Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10021.ORCID 0000-0001-6153-8793
Olivier ElementoEnglander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021.ORCID 0000-0002-8061-9617
Melissa B DavisEnglander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York, NY10021.ORCID 0000-0002-6124-6923
Olorunseun OgunwobiThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0000-0003-3388-2137
Jill BargonettiThe Department of Biological Sciences Hunter College, Belfer Building, City University of New York, New York, NY10021.ORCID 0000-0003-2692-0991

Funding

RISE Program Hunter College Option IIIR25GM060665 · NIGMS · HUNTER COLLEGE · PI ORTIZ, BENJAMIN D.,, SERRANO, PETER A · 2000 to 2022
$22.8M
TUFCCC/HC Regional Comprehensive Cancer Health PartnershipU54CA221704 · NCI · HUNTER COLLEGE · PI Joel Erblich, Jennifer S Ford · 2018 to 2026
$10.6M
The DARC side of Breast Cancer Disparities - African Ancestry and Cancer- Related Immune ResponseR01CA259396 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAVIS, MELISSA B, YATES, CLAYTON · 2021 to 2025
$2.4M
The Role of the Mutant p53-PARP-MCM Pathway in Triple Negative Breast CancerR01CA239603 · NCI · HUNTER COLLEGE · PI BARGONETTI, JILL E. · 2020 to 2024
$1.8M
CANCER GRAND CHALLENGES 2024 SOCIETAL, ANCESTRY, MOLECULAR AND BIOLOGICAL ANALYSES OF INEQUALITIES (SAMBAI) Morehouse School of MedicineOT2CA297574 · NCI · MOREHOUSE SCHOOL OF MEDICINE · PI DAVIS, MELISSA B · 2024 to 2024
$614k
NCI NIH HHS OT2 CA297574NCI NIH HHS R01 CA239603NCI NIH HHS R01 CA259396NCI NIH HHS U54 CA221704NIGMS NIH HHS R25 GM060665
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Major: Biological SciencesMetastasisMinor: Cell BiologyMutant p53PARPPARP inhibitorReplication stressTNBC

Identifiers

PMID41928956
PMCPMC13041838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.