ArticleRSC chemical biology2026
Guanine base modifications in antisense oligonucleotides mitigate acute central nervous system toxicity.
Maho Katsuyama, Taiki Matsubayashi, Yang Ying, Su Su Lei Mon, Takayuki Kuroda, Kie Yoshida-Tanaka, Rintaro Iwata Hara, Takeshi Yamada, Kumiko Ui-Tei, Kotaro Yoshioka
Abstract read
In one paragraphArticle in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Maho KatsuyamaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.
Taiki MatsubayashiDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.
Yang YingDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.
Su Su Lei MonDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.
Takayuki KurodaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.
Kie Yoshida-TanakaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.
Rintaro Iwata HaraDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.ORCID https://orcid.org/0000-0003-2399-3431 Takeshi YamadaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.ORCID https://orcid.org/0000-0003-3275-415X Kumiko Ui-TeiCenter for Brain Integration Research, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 Tokyo Japan.
Kotaro YoshiokaDepartment of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo 1-5-45 Yushima, Bunkyo-Ku Tokyo 113-8519 Japan kotanuro@md.isct.ac.jp.ORCID https://orcid.org/0000-0001-7094-9017 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Antisense oligonucleotides (ASOs) are recognized as promising therapeutic agents for central nervous system (CNS) diseases. However, neurotoxicity induced by ASOs
Identifiers
PMID41928909
PMCPMC13040562
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