Evidence map›Paper›PMID 41928878›Full record

ArticleFrontiers in endocrinology2026

A drop in serum estradiol levels during GnRH antagonist cotreatment in cycles stimulated with gonadotropins is associated with lower cumulative live birth rates.

Lara Janssens, Ella Roelant, Christophe Blockeel, Diane De Neubourg

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lara JanssensDepartment Center for Reproductive Medicine, Antwerp University Hospital, Edegem, Belgium.
Ella RoelantClinical Trial Center (CTC), CRC Antwerp, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Christophe BlockeelBrussels IVF, Centre for Reproductive Medicine, Brussels University Hospital, Brussel, Belgium.
Diane De NeubourgDepartment Center for Reproductive Medicine, Antwerp University Hospital, Edegem, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last decades, the gonadotropin-releasing hormone (GnRH) antagonist protocol has become widely used for prevention of premature luteinizing hormone surge during ovarian stimulation with exogenous gonadotropins. Literature has shown its efficacy and safety, while maintaining similar live birth rates compared to agonist protocols. Clinicians occasionally notice a drop in serum estradiol levels after GnRH antagonist initiation. This study aimed to analyze the impact of a drop in serum estradiol levels after the administration of a GnRH antagonist on clinical outcomes in

Indexed as

EstradiolGonadotropin-Releasing HormoneGonadotropinsHormone AntagonistsLive BirthOvulation InductionAdultBirth RateFemaleFertilization in VitroHumansLuteinizing HormonePregnancyPregnancy RateSperm Injections, IntracytoplasmicEstradiolGonadotropin-Releasing HormoneGonadotropinsHormone AntagonistsLuteinizing Hormoneassisted reproductive technologyestradiolGnRH antagonistin vitro fertilizationovarian stimulation

Identifiers

PMID41928878
PMCPMC13038525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.