Evidence map›Paper›PMID 41928813›Full record

ArticleResearch square2026

CLOCK is an Epigenetic Integrator of Circadian Rhythm and T Cell Immunity.

Shirin Eyvazi, Abu Osman, Abdulrahman Saadalla, Mahendra Pal Singh, Cameron Marlow, Ali Keshavarzian, Faraz Bishehsari, Iradj Sobhani, Aleksey Matveyenko, Fotini Gounari and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shirin EyvaziDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, United States, USA.
Abu OsmanDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, United States, USA.
Abdulrahman SaadallaDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Mahendra Pal SinghDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, United States, USA.
Cameron MarlowDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, United States, USA.
Ali KeshavarzianDepartment of Internal Medicine RUSH, Chicago, Illinois, USA.
Faraz BishehsariDepartment of Internal Medicine, University of Texas Health Science Center, Houston, Texas, USA.
Iradj SobhaniDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Aleksey MatveyenkoDepartment of Internal Medicine RUSH, Chicago, Illinois, USA.
Fotini GounariDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, United States, USA.ORCID 0000-0003-2936-066X
Khashayarsha KhazaieDepartment of Immunology, Mayo Clinic, Phoenix, Arizona, United States, USA.ORCID 000-0002-7884-1817

Funding

Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogenR01CA264048 · NCI · MAYO CLINIC ARIZONA · PI BOARDMAN, LISA ALLYN, GOUNARI, FOTINI · 2021 to 2025
$3.1M
NCI NIH HHS R01 CA264048
6 · The paper itself

Abstract

The circadian clock imposes a critical yet incompletely understood layer of regulation on adaptive immunity. T helper 17 (Th17) antimicrobial immune responses including expression of IL-17A by lamina propria CD4

Indexed as

BMAL1Circadian RhythmCLOCKEpigeneticsImmune SignalingNaïve CD4 T Cell Lineage Specification

Identifiers

PMID41928813
PMCPMC13042162

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.