ArticleAesthetic surgery journal. Open forum2026
Study on Age-Related Facial Fat Changes Using 3D MRI and a Novel Algorithm.
Article in Aesthetic surgery journal. Open forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Age-related changes in facial and cervical fat distribution play a critical role in aesthetic appearance; yet, quantitative evidence remains limited. Objectives: This study aimed to quantitatively characterize regional fat distribution patterns of the neck and face across different age groups using advanced imaging, and to examine the relationships between age, body mass index (BMI), and fat distribution. Methods: A cross-sectional study was conducted in 47 healthy female participants aged 18-65 years. High-resolution 3-dimensional magnetic resonance imaging (3D MRI) was used to measure fat thickness and volume across predefined anatomical compartments. Results: Neck fat thickness and volume showed significant positive correlations with both age and BMI, with the greatest increases observed in midlife. Facial fat demonstrated region-specific remodeling rather than uniform descent. Buccal fat pad and nasolabial fold volumes significantly decreased with age, whereas upper facial superficial fat remained stable. Infraorbital fat volume and thickness exhibited a distinct age-related increasing trend, particularly between young and middle-aged groups. Conclusions: This study reveals potential heterogeneous age-related changes in facial and cervical fat distribution through quantitative imaging analysis. Our findings suggest that distinct fat compartments may age at different rates, which could have implications for understanding facial ageing and related interventions. Level of Evidence 3 Therapeutic:
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