ArticleNeurogastroenterology and motility2026
Short-Chain Fatty Acids Activate Myenteric Neurons and Delay Colonic Motility via Free Fatty Acid Receptors 2 and 3 in the Mouse.
Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundShort-chain fatty acids (SCFAs), metabolic products of the gut microbiota, are important regulators of intestinal homeostasis. SCFAs exert their effects through free fatty acid receptors (FFAR), which are located on enteroendocrine cells and enteric nerves. The actions of SCFAs include the regulation of motility. How SCFAs affect enteric neuronal activity and the regulation of colonic motility remains to be fully elucidated.
methodsIntact preparations of the proximal colon from mice expressing a genetically encoded fluorescent Ca KEY
resultsIn Calb1-GCaMP6 mice, propionate exhibited the highest and most sustained Ca CONCLUSIONS AND INFERENCES: Acutely, luminal administration of SCFAs activates myenteric neurons and slows colonic transit through FFAR2 and FFAR3 receptors.
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