ArticlePhysiological reports2026
Sex differences in IL-6 responses to moderate-intensity aerobic exercise are explained by cycling power output.
Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Biomarkers of exercise-induced muscle damage and inflammation across menstrual cycle phases: a critical review.Frontiers in sports and active living · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
This study characterized interleukin-6 (IL-6) and derivative-reactive oxygen metabolites (d-ROMs) responses to moderate-intensity exercise in healthy adults and assessed whether sex differences were due to workload. Fifteen males (26.5 ± 2.9 years, BMI: 23.7 ± 3.1) and 14 females (25.7 ± 2.8 years, BMI: 21.2 ± 1.8 in the menstrual phase (MP) and 21.8 ± 2.1 in the luteal phase (LP)) completed 60 min of cycling at 65 ± 5% of predicted maximal heart rate. Power output was 42.8 ± 11.8 W (MP), 44.0 ± 14.1 W (LP), and 78.8 ± 26.9 W (males) (MP vs. males and LP vs. males: p < 0.001). IL-6 and d-ROMs were measured before (Pre), immediately after (Post0), and 60 min after exercise (Post60), and group × time effects were tested using linear mixed-effects models. IL-6 showed a group × time interaction. Males had greater IL-6 responses than females at Post0 (MP vs. males: p < 0.001; LP vs. males: p < 0.05), but these differences were not significant after adjusting for power output. d-ROMs showed no significant changes over time or by group. Power output correlated with carbohydrate oxidation. These findings suggest that, at the same relative intensity, sex differences in IL-6 responses reflect workload.
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