Evidence map›Paper›PMID 41928215›Full record

SynthesisBMC oral health2026

Efficacy and safety of dexmedetomidine in orthognathic surgery: a systematic review and meta-analysis.

Ahmad M Molhem, Hanan M Qasem, Abdullah Yousef Aldalati, Qussai R Abuelsamen, Haya B Abukharmh, Tamara M Molhem, Rania Anwar Ayasrah, Heider Sultan Sheyyab, Mariam Kawafha, Mohammed Al-Mahdi Al-Kurdi and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Ahmad M Molhem *MD, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan.
Hanan M Qasem *BDS, Faculty of Dentistry, Jordan University of Science and Technology (JUST), Irbid, Jordan.
Abdullah Yousef AldalatiMD, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan.
Qussai R AbuelsamenMD, Faculty of Medicine, University of Jordan, Amman, Jordan.
Haya B AbukharmhBPharm, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.
Tamara M MolhemFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Rania Anwar AyasrahJordanian Royal Medical Services, Endodontics Specialist, Amman, Jordan.
Heider Sultan SheyyabMD, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan.
Mariam KawafhaFaculty of Nursing, Yarmouk University, Irbid, Jordan.
Mohammed Al-Mahdi Al-KurdiFaculty of Medicine, University of Aleppo, Aleppo, Syria. mohammedmahdikurdi@gmail.com.
Alhussein HasanatBDS, JBOMS, FFDRCSI, FDSRCSE, Craniofacial Reconstructive Surgery - Plastic Surgery Department, Stanford University, Stanford, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOrthognathic surgery improves dentofacial function and aesthetics, but it’s usually associated with postoperative pain, hemodynamic instability and postoperative nausea/vomiting. Dexmedetomidine, a hypotensive agent, is known for its sedative and analgesic properties in various surgical procedures. This study aims to evaluate its efficacy and safety in orthognathic surgery.

methodsWe followed PRISMA guidelines throughout the entire process. We searched the following medical databases: PubMed, Embase, Cochrane Library, Web of Science and Scopus. Randomized controlled trials and cohorts on dexmedetomidine in orthognathic surgery were screened and retrieved according to predefined criteria. Primary outcomes include blood loss, anesthesia time, operation time, MAP (mean arterial pressure) and heart rate. R studio software was employed for all analyses indicated.

resultsEight studies, including 1,432 participants, were included in the review, with 7 of them contributing to the analysis. Compared to controls, our meta-analysis revealed that patients on dexmedetomidine showed significantly shorter anesthesia time (MD: -40.75, 95%CI [-74.21; -7.29], P = 0.03) and significantly lower heart rate (MD: -12.99, 95%CI [-23.23; -2.75], P = 0.03). A non-significant reduction in blood loss (MD: -119.13, 95%CI [-333.17; 94.92], P = 0.21) and MAP (MD: -2.47, 95%CI [-8.26; 3.31], P = 0.27) was also observed.

conclusionsOur results support the clinical utility of dexmedetomidine in patients undergoing orthognathic surgery. It significantly shortens anesthesia duration and reduces heart rate, with a statistically nonsignificant trend toward reduced intraoperative blood loss.

Indexed as

Analgesics, Non-NarcoticDexmedetomidineHypnotics and SedativesOrthognathic Surgical ProceduresBlood Loss, SurgicalHeart RateHumansOperative TimeAnalgesics, Non-NarcoticDexmedetomidineHypnotics and SedativesBlood lossControlled hypotensionDexmedetomidineOrthognathic surgery

Identifiers

PMID41928215
PMCPMC13170157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.