Trial reportBMC oral health2026
Effect of topical application of atorvastatin gel versus hyaluronic acid on immediate loading dental implant in posterior maxilla: a randomized controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06976866 (Effect of Topical Application of Atorvastatin Gel Versus Hyaluronic Acid on Immediate Loading Dental Implant in Posterior Maxilla), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Effect of Topical Application of Atorvastatin Gel Versus Hyaluronic Acid on Immediate Loading Dental Implant in Posterior Maxilla
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImmediate loading protocols are increasingly popular, but the complex anatomy of the posterior maxilla presents challenges. Comparative studies on the effects of hyaluronic acid (HA) and atorvastatin gel (ATV) on bone density in this region are limited. This study aimed to compare the impact of topical HA and ATV gels on bone density around immediately loaded implants in the posterior maxilla. MATERIALS AND
methodsTwenty-one patients were randomly and equally assigned to three groups (n = 7 per group): Group I (Control): Received implants without any coating. Group II (HA group): Received implants coated with HA gel. Group III (ATV group): Received implants coated with atorvastatin (ATV) gel. Clinical evaluation of implant stability was conducted at the time of insertion and at 3 and 6 months postoperatively. Peri-implant pocket depth (PPD) and modified sulcus bleeding index (mSBI) were also assessed. Radiographic evaluation of buccal bone density (BD) was performed using cone-beam computed tomography (CBCT) immediately after implant loading and again at 6 months. All clinical and radiographic data were subjected to statistical analysis.
resultsAfter 6 months, there was a statistically significant increase in buccal bone density in both Group II (HA) and Group III (ATV) compared to the control group (p = 0.001). No significant difference was found between the HA and ATV groups. There were no statistically significant differences among the three groups regarding implant stability, PPD, or mSBI (p > 0.05).
conclusionHA and ATV gels increased buccal bone density but did not significantly improve implant stability or peri-implant health versus controls.
trial registrationThe study was listed on www.clinicaltrials.gov with registration number (NCT06976866) on 09/05/2025.
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