Trial reportBMC oral health2026
Effect of calcium silicate and epoxy resin-based sealers on postoperative pain: a randomized clinical trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPostoperative pain is a common complication after endodontic treatment and may be influenced by obturation techniques and sealer properties. Calcium silicate-based sealers have gained attention for their bioactive properties; however, their clinical performance with respect to postoperative pain and healing outcomes remains uncertain. This randomized, double-blind clinical trial aimed to compare postoperative pain and healing outcomes following root canal obturation with a calcium silicate-based sealer (CSBS) versus an epoxy resin-based sealer (ERBS).
methodsSeventy-two adult patients requiring endodontic treatment were randomly assigned to two groups based on the sealer used for obturation: Bio-C Sealer (CSBS) or AH Plus Jet (ERBS). Root canal preparation was performed using a reciprocating system, and obturation was carried out using the thermocompaction technique. Postoperative pain was assessed using a numerical rating scale (0–10) at 6, 12, 24, 48, and 72 hours after treatment. Rescue medication use was recorded. Radiographic healing was evaluated after 12 months using the Periapical Index (PAI).
resultsNo significant differences were observed between groups in postoperative pain occurrence at any evaluated time point (p > 0.05). The risk of postoperative pain was 4.5 times higher when extrusion of filling material occurred (RR = 4.55; 95% CI: 1.25–16.62). Younger participants showed a higher risk of postoperative pain within the first 24 hours (RR = 3.20; 95% CI: 1.33–7.74). Rescue medication use decreased over time, with no differences between groups. At the 12-month follow-up, 53 participants were evaluated, and similar healing outcomes were observed (Bio-C Sealer: 1.04 ± 0.21; AH Plus Jet: 1.04 ± 0.19; p > 0.05).
conclusionsBoth sealers showed similar postoperative pain and healing outcomes. Filling material extrusion was the main factor associated with increased postoperative pain.
trial registrationThis study was registered with the Brazilian Clinical Trials Registry (ReBEC) (RBR-8s5cbfk) on 2022-03-08.
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