ArticleBMC nephrology2026
Comparison of estimated and measured GFR in pediatric CKD patients transitioning from adolescence to adulthood: results from KNOW-PedCKD.
Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAccurate estimation of glomerular filtration rate (eGFR) is essential for managing pediatric chronic kidney disease (CKD). While multiple eGFR equations are used clinically, their reliability in adolescents transitioning to adulthood with pediatric-onset CKD remains uncertain. This study aimed to evaluate the accuracy of 10 eGFR equations against measured GFR (mGFR) values in South Korean adolescents and young adults with CKD using data from the KoreaN Cohort Study for Outcomes in Patients With Pediatric Chronic Kidney Disease (KNOW-PedCKD) cohort.
methodsPatients aged ≥ 15 years who underwent mGFR testing were included in the KNOW-PedCKD study. mGFR was determined using plasma clearance of
resultsThe analysis encompassed 187 mGFR measurements from 82 patients (median age 18.4 years, interquartile range (IQR) 16.5-20.8; 75.9% male). Median mGFR was 42.3 (19.3-70.5) mL/min/1.73 m
conclusionsThe eGFR equations covering children - particularly U25
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