Evidence map›Paper›PMID 41928119›Full record

ArticleBMC nephrology2026

Impacts of preoperative kidney function and acute kidney injury on long-term kidney failure after cardiac surgery: a registry-based cohort study.

Dominic Keuskamp, Christopher E Davies, Robert A Baker, Kevan R Polkinghorne, Christopher M Reid, Julian A Smith, Lavinia Tran, Jenni Williams-Spence, Rory Wolfe, Stephen P McDonald

Abstract read
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Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dominic KeuskampAustralia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA, 5001, Australia. dominic.keuskamp@adelaide.edu.au.ORCID 0000-0003-3214-3682
Christopher E DaviesAustralia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA, 5001, Australia.
Robert A BakerCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Kevan R PolkinghorneDepartment of Nephrology, Monash Health, Clayton, VIC, Australia.
Christopher M ReidSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Julian A SmithDepartment of Surgery (School of Clinical Sciences at Monash Health), Monash University, Clayton, VIC, Australia.
Lavinia TranSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Jenni Williams-SpenceSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Stephen P McDonaldAustralia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, PO Box 11060, Adelaide, SA, 5001, Australia.

Funding

National Health and Medical Research Council,Australia 1173941
6 · The paper itself

Abstract

backgroundAcute kidney injury is a common complication of cardiac surgery and may lead to kidney failure. In a large sample sourced from national registries, we estimated the risk of kidney failure up to nine years following cardiac surgery and the associations with acute kidney injury, comorbidities and preoperative estimated glomerular filtration rate.

methodsData were linked probabilistically between population-based registries to identify adults with kidney failure (commencement of long-term kidney replacement therapy) following cardiac surgery. Risk of kidney failure accounting for the competing risk of death was estimated from 30 days following surgery using Fine-Gray models. Surgeries from 2010 to 2018 were included (n = 90 605) with follow-up until the end of 2018.

resultsA total of 465 adults (0.51%) developed kidney failure during follow-up and the cumulative incidence at five years was 0.65% (95% CI 0.59, 0.73). The risk of kidney failure increased with decreasing estimated glomerular filtration rate. The rate of any acute kidney injury was 26.2% and all stages were associated with kidney failure. For Stage 3 acute kidney injury compared with none, the adjusted subdistribution hazard ratio of kidney failure exceeded 4.4 at all intervals following surgery.

conclusionAcute kidney injury presented an enduring risk of kidney failure following cardiac surgery, independent of baseline estimated glomerular filtration rate. People comorbid with diabetes also experienced a high adjusted risk of kidney failure. All patients could benefit from perioperative management optimized to prevent acute kidney injury and regular postoperative nephrology follow-up for more than a year to mitigate the burden of kidney disease on the health system. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresPostoperative ComplicationsRenal InsufficiencyAgedCohort StudiesFemaleGlomerular Filtration RateHumansIncidenceMaleMiddle AgedPreoperative PeriodRegistriesRisk FactorsAcute kidney injuryCardiac surgeryChronic kidney diseaseKidney failureKidney replacement therapy

Identifiers

PMID41928119
PMCPMC13169865

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.