Evidence map›Paper›PMID 41928106›Full record

ArticleBMC gastroenterology2026

Vitamin D receptor gene polymorphism and its association with the susceptibility to Helicobacter pylori infection in the Egyptian population with hepatocellular carcinoma.

Asmaa Ibrahim, Shaymaa Abdelraheem Abdelhady, Fatma Rageh, Rasha Elgamal, Mohamed Medhat, Reham F Othman, Hend A Yassin, Yasmine N Kamel, Eman M Osman, Almaza Ali Salim and 3 more

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Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Asmaa IbrahimGenetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), Sadat, Egypt. chemistasmaain@gmail.com.ORCID http://orcid.org/0000-0001-8119-9549
Shaymaa Abdelraheem AbdelhadyDepartment of Clinical Pathology, Suez Canal University, Suez, Egypt.
Fatma RagehDepartment of Infectious Diseases, Gastroenterology, and Hepatology, Faculty of Medicine, Suez University, Suez, Egypt.
Rasha ElgamalDepartment of Clinical Pathology, Faculty of Medicine, Suez University, Suez, Egypt.
Mohamed MedhatDepartment of Infectious Diseases, Gastroenterology, and Hepatology, Faculty of Medicine, Suez University, Suez, Egypt.
Reham F OthmanDepartment of Medicine, School of Medicine, Newgiza University, Giza, Egypt.
Hend A YassinDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Yasmine N KamelDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Eman M OsmanDepartment of Immunology and Allergy, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Almaza Ali SalimDepartment of Family Medicine, Faculty of Medicine, Port Said University, Port Said, Egypt.
Samar S AhmedDepartment of Public Health and Occupational Medicine, Faculty of Medicine, Suez University, Suez, Egypt.
Reham Mohamed ShakerDepartment of Nephrology, Faculty of Medicine, Suez University, Suez, Egypt.
Doaa EltaweelDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to estimate the frequency of H. pylori infection in patients with liver disorders, and identify the relationship between vitamin D receptor gene variants and susceptibility to H. pylori infections and HCC in Egyptian patients with liver diseases. MATERIALS AND

methodsThis study consists of 300 adult patients classified into three groups: 100 healthy controls, 100 patients with liver cirrhosis, and 100 patients with HCC. Every patient was assessed for the presence of H. pylori by rapid test and polymerase chain reaction (PCR). Estimation of FokI and BsmI VDR gene polymorphism was performed by restriction fragment length polymorphism-Polymerase chain reaction (RFLP-PCR).

resultsInfection with H. pylori was present in 46.7% of cases overall. Liver cirrhosis (LC) patients had a higher prevalence of H. pylori infection, followed by HCC patients (59% and 42%, respectively). Patients with LC and HCC were shown to be CagA positive, with the target CagA oncogene gene having an expected product size of 37.3% and 35.7%, respectively. LC and HCC patients showed a significant difference between the H. pylori-positive and -negative groups. Concerning the BsmI polymorphism, HCC patients with H. pylori-CagA positive had a higher GC genotype than those with H. pylori-CagA negative, and LC and HCC patients with H. pylori-CagA positive had a higher TT genotype than those with H. pylori-CagA negative.

conclusionFokI and BsmI VDR polymorphisms may be linked to H. pylori infection and CagA strain susceptibility in patients with LC and HCC.

Indexed as

Carcinoma, HepatocellularHelicobacter InfectionsHelicobacter pyloriLiver CirrhosisLiver NeoplasmsPolymorphism, GeneticReceptors, CalcitriolAdultAntigens, BacterialBacterial ProteinsCase-Control StudiesEgyptFemaleGenetic Predisposition to DiseaseHumansMaleAntigens, BacterialBacterial ProteinscagA protein, Helicobacter pyloriReceptors, CalcitriolVDR protein, humanEgyptianHelicobacter pyloriLiver diseasesPolymorphismSusceptibilityVitamin D receptor

Identifiers

PMID41928106
PMCPMC13063462

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.