Evidence map›Paper›PMID 41928006›Full record

ArticleThe EMBO journal2026

A spontaneous termination mechanism of RNA polymerase V shapes the DNA methylation landscape in plants.

Guohui Xie, Xuan Du, Yifang Tan, Yuxing Zhou, Cheng Chi, Sixian Zhou, Colette L Picard, Songge Chai, Lei Wu, Danling Zhu and 6 more

Abstract read
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Guohui Xie *Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0003-4734-9114
Xuan Du *Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Key Laboratory of High-Efficiency Utilization of Light in Plants, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.ORCID http://orcid.org/0000-0001-9589-3566
Yifang Tan *Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Yuxing Zhou *Department of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-9065-7908
Cheng Chi *Shandong Laboratory of Advanced Agricultural Sciences at Weifang, Peking University Institute of Advanced Agricultural Sciences, Weifang, China.
Sixian ZhouShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Colette L PicardDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2177-2216
Songge ChaiShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0009-0001-6773-8005
Lei WuShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0009-0003-9757-3795
Danling ZhuShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0003-3385-403X
Jun ZhaoShandong Laboratory of Advanced Agricultural Sciences at Weifang, Peking University Institute of Advanced Agricultural Sciences, Weifang, China.ORCID http://orcid.org/0009-0006-6190-0469
Yan XueShandong Laboratory of Advanced Agricultural Sciences at Weifang, Peking University Institute of Advanced Agricultural Sciences, Weifang, China.ORCID http://orcid.org/0000-0003-0871-8853
Sisi LiInternational Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen, China.ORCID http://orcid.org/0000-0002-7290-8128
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California at Los Angeles, Los Angeles, CA, USA. jacobsen@ucla.edu.ORCID http://orcid.org/0000-0001-9483-138X
Zhe WuShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. wuz@sustech.edu.cn.ORCID http://orcid.org/0000-0001-9436-3299
Jiamu DuShenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. dujm@sustech.edu.cn.ORCID http://orcid.org/0000-0002-1337-0786

Funding

GDSTC | Natural Science Foundation of Guangdong Province () 2023B1515120048Howard Hughes Medical Institute (HHMI) N.A.MOST | National Natural Science Foundation of China (NSFC) 32325008MOST | National Natural Science Foundation of China (NSFC) 323B2041| Natural Science Foundation of Shenzhen Municipality (Shenzhen Natural Science Foundation) JCYJ20240813094610015| Natural Science Foundation of Shenzhen Municipality (Shenzhen Natural Science Foundation) RCJC20221008092720004| Natural Science Foundation of Shenzhen Municipality (Shenzhen Natural Science Foundation) RCJC20231211085924032| Natural Science Foundation of Shenzhen Municipality (Shenzhen Natural Science Foundation) RCJC20231211085945061| Natural Science Foundation of Shenzhen Municipality (Shenzhen Natural Science Foundation) ZDSYS20230626091659010| Postdoctoral Research Foundation of China (China Postdoctoral Research Foundation) 2024M761288Shenzhen Medical Research Fund A2303024SUSTech Institute for Biological Electron Microscopy N.A.
6 · The paper itself

Abstract

DNA methylation plays critical roles in eukaryotic gene silencing, genome imprinting, viral defense, and suppression of transposable elements. In plants, RNA Polymerase V (Pol V)-generated non-coding RNA guides DNA methylation through the RNA-directed DNA methylation (RdDM) pathway; however, how these RNAs are selected is unknown. Here, we show that the 3'-ends of Pol V transcripts are enriched at A-rich template DNA (A-rich-DNA

Indexed as

ArabidopsisArabidopsis ProteinsDNA-Directed RNA PolymerasesDNA MethylationTranscription Termination, GeneticDNA, PlantGene Expression Regulation, PlantRNA, PlantTranscription, GeneticArabidopsis ProteinsDNA-Directed RNA PolymerasesDNA, PlantRNA, PlantRNA polymerase V, ArabidopsisRNA-directed DNA MethylationRNA Polymerase VSpontaneous TerminationStructural BiologyTranscription

Identifiers

PMID41928006
PMCPMC13144423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.