Evidence map›Paper›PMID 41927946›Full record

ArticleNature chemistry2026

Programmable divergent electrochemical ring-opening multifunctionalization of strained rings.

Yajuan Li, Yatao Lang, Shu-Fan He, Daixi Li, Ke-Xin Liu, Wenying Ai, Yong Jiang, Chen Zhu, Tao Shen

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Floquet States of Chemoselective Alternating Current Electrosynthesis.Journal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yajuan LiFrontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yatao LangEastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, People's Republic of China.
Shu-Fan HeFrontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Daixi LiDepartment of Respiratory and Critical Care Medicine, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People's Republic of China. lidaixi@xmu.edu.cn.ORCID http://orcid.org/0000-0001-7293-2008
Ke-Xin LiuCollege of Chemistry and Molecular Sciences, Henan University, Zhengzhou, People's Republic of China.
Wenying AiCollege of Chemistry and Molecular Sciences, Henan University, Zhengzhou, People's Republic of China. 6786@zut.edu.cn.ORCID http://orcid.org/0000-0001-5488-0048
Yong JiangEastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, People's Republic of China.
Chen ZhuEastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo, People's Republic of China. chen.zhu@eitech.edu.cn.ORCID http://orcid.org/0000-0002-8997-2281
Tao ShenFrontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, People's Republic of China. taoshen@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-2028-152X

Funding

National Natural Science Foundation of China (National Science Foundation of China) No.22301179, No.22471156National Natural Science Foundation of China (National Science Foundation of China) No.22401164Natural Science Foundation of Fujian Province (Fujian Provincial Natural Science Foundation) 2021J05280
6 · The paper itself

Abstract

The ring-opening functionalization of strained rings represents a highly valuable transformation. However, existing strategies predominantly focus on ring-opening difunctionalization, as initial derivatization typically diminishes the reactivity of surrounding C-H bonds. Consequently, the selective control over site, regio and oxidation state among multiple inert C-H/C-C bonds remains a major unmet challenge. Here we report a multisite programmable, divergent ring-opening functionalization of strained rings via electro-oxidation of continuous C-C bond and multiple C(sp

Identifiers

PMID41927946

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.