Evidence map›Paper›PMID 41927931›Full record

ArticleCell research2026

Chemical reprogramming directly resets mouse post-implantation epiblast cells to a totipotent state.

Hai Zhou, Xuzhao Zhai, Chikai Zhou, Junyu Chen, Xiukun Wang, Ling Li, Wenwen Shi, Shu Sun, Guokai Chen, Guang Hu and 2 more

Abstract readLetter
In one paragraph

Article in Cell research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hai Zhou *GMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xuzhao Zhai *GMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China.
Chikai Zhou *Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0001-9653-3466
Junyu ChenGMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiukun WangEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Ling LiGMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China.
Wenwen ShiGMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China.
Shu SunGMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China.
Guokai ChenDepartment of Biomedical Sciences and Centre of Reproduction, Development and Aging (CRDA), Faculty of Health Sciences, University of Macau, Taipa, China.ORCID http://orcid.org/0000-0003-0921-8244
Guang HuEpigenetics and RNA Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Erwei ZuoShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0001-8259-0275
Man ZhangGMU-GIBH Joint School of Life Sciences, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou National Laboratory, Guangzhou Medical University, Guangzhou, Guangdong, China. zhang_man@gzlab.ac.cn.ORCID http://orcid.org/0000-0002-4704-4356

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32570958National Natural Science Foundation of China (National Science Foundation of China) W2533083
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41927931
PMCPMC13092638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.