Evidence map›Paper›PMID 41927921›Full record

ArticleCommunications biology2026

Gestational choline supplementation regulates hippocampal granule neuron development and emotion-like behavior.

Xiaohui Shi, Yuanyuan Li, Mengjiao Wang, Xinlan Zong, Min Liang, Quan Li, Weiwei Xiao, Zhongsheng Sun, Yan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaohui ShiInterdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0009-0007-6307-0857
Yuanyuan LiCollege of Life Sciences, University of the Chinese Academy of Sciences, Beijing, China.
Mengjiao WangInterdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Xinlan ZongInterdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Min LiangInterdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Quan LiSchool of Life Sciences, Hebei University, Baoding, China.
Weiwei XiaoInterdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Zhongsheng SunInterdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. sunzs@biols.ac.cn.ORCID http://orcid.org/0000-0002-7640-5026
Yan WangInterdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. yanwang@ioz.ac.cn.ORCID http://orcid.org/0000-0001-7689-4942

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal nutrition can profoundly influence the brain development of offspring through mechanisms including epigenetic reprogramming. However, the complex interplay of maternal nutrition, neural development, and behaviors at the cellular level remains to be explored. Here, we report that gestational choline supplementation (GCS) in mice attenuates anxiety- and depression-like behaviors in male offspring (F1

Indexed as

Behavior, AnimalCholineDietary SupplementsEmotionsHippocampusNeurogenesisNeuronsAnimalsAnxietyFemaleMaleMiceNeurodevelopmentPregnancyCholine

Identifiers

PMID41927921
PMCPMC13219442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.