Evidence map›Paper›PMID 41927834›Full record

ArticleNature immunology2026

A unique CD4⁺ T cell subset expressing granzyme K is regulated by transcription factor EOMES and important for T cell-mediated intestinal inflammation.

Tian Xie, Yizhou Du, Qihan Wang, Hao Zhang, Kun Wei, Xinxin Chi, Xue Bai, Yujie Fu, Zhilin Peng, Yicheng Zhu and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. A new 'K'ind of T helper cell.Nature immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tian XieInstitute for Immunology and School of Basic Medical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0003-2240-8202
Yizhou DuWestlake University School of Medicine and New Cornerstone Laboratory, Hangzhou, China.ORCID http://orcid.org/0000-0001-5111-9827
Qihan WangWestlake University School of Medicine and New Cornerstone Laboratory, Hangzhou, China.
Hao ZhangInstitute for Immunology and School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Kun WeiInstitute for Immunology and School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Xinxin ChiInstitute for Immunology and School of Basic Medical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0003-2120-6684
Xue BaiInstitute for Immunology and School of Basic Medical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-9059-3078
Yujie FuInstitute for Immunology and School of Basic Medical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0003-4828-9459
Zhilin PengWestlake University School of Medicine and New Cornerstone Laboratory, Hangzhou, China.
Yicheng ZhuWestlake University School of Medicine and New Cornerstone Laboratory, Hangzhou, China.
Qiuyan LanWestlake University School of Medicine and New Cornerstone Laboratory, Hangzhou, China.ORCID http://orcid.org/0000-0003-0984-6259
Chen DongWestlake University School of Medicine and New Cornerstone Laboratory, Hangzhou, China. dongchen@westlake.edu.cn.ORCID http://orcid.org/0000-0002-0084-9130

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32550002National Natural Science Foundation of China (National Science Foundation of China) 82402058
6 · The paper itself

Abstract

CD4⁺ helper T (T

Indexed as

CD4-Positive T-LymphocytesColitisGranzymesT-Box Domain ProteinsT-Lymphocyte SubsetsAnimalsCell DifferentiationDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutEOMES protein, humanEomes protein, mouseGranzymesT-Box Domain Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.