ArticleScientific reports2026
The mediating role of fasting plasma glucose and systolic blood pressure in the association between Chinese visceral adiposity index and carotid atherosclerosis: a cross-sectional study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Visceral adipose tissue dysfunction is a key driver of cardiometabolic disease, yet the pathways linking it to atherosclerosis remain incompletely understood. This cross-sectional study included 6767 adults from a general health check-up population in Shanghai and investigated the association between the Chinese Visceral Adiposity Index (CVAI) and carotid atherosclerosis (CAS), as well as the mediating roles of systolic blood pressure (SBP) and fasting plasma glucose (FPG) using parallel mediation analysis. After full adjustment for confounders, each standard deviation (SD) increase in CVAI was associated with 37% higher odds of CAS (OR 1.37, 95% CI 1.26–1.49), demonstrating a significant linear dose-response relationship (P-overall < 0.001). Parallel mediation analysis revealed that SBP and FPG jointly mediated 59.2% of the total effect of CVAI on CAS, with SBP and FPG accounting for 36.0% and 23.2%, respectively, while a significant direct effect persisted (40.8%, P = 0.025). The association was consistent across all subgroups without significant interaction (all P-interaction > 0.05). This study quantifies the substantial parallel mediating roles of SBP and FPG in the CVAI–CAS association, highlighting the potential relevance of blood pressure and glycemic pathways in linking visceral adiposity to atherosclerosis risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.