ArticleScientific reports2026
Laboratory-based cellular-level correlative visible-light and X-ray microscopy for 3D evaluation of mouse kidney biopsy.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
X-ray microscopy (XRM) is an emerging technology for nondestructive evaluation of bio-specimen. We previously reported that paraffin, which is used for normal histology, acts as a tissue contrast enhancement agent in XRM, thereby enabling cellular-level 3D visualization of unstained biological samples. In this work, a new form of correlative visible-light and X-ray microscopy (CLXM) was introduced, where a kidney biopsy sample was first observed by laboratory-based XRM with paraffin-mediated contrast enhancement, and the same sample was then observed by visible-light microscopy (LM) at the same measurement point, to compare images from these two modalities precisely. This laboratory-based cellular-level CLXM was applied to a kidney biopsy from a 5/6 nephrectomy model mouse to evaluate glomerular hypercellularity lesions. The image comparison identified high-opacity particles in XRM images as cell nuclei in various parts of the nephron including glomeruli and tubules. A complementary approach using both LM and XRM images allowed us to identify/segment three lesions as aggregations of mesangial cells. It was found that one mesangial cell occupied a volume of about 100 μm
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