Evidence map›Paper›PMID 41927689›Full record

ArticleScientific reports2026

Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase including catalytic intermediates suggest an ordered Bi-Bi reaction mechanism.

Kazuaki Matoba, Takeshi Nara, Takashi Aoki, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Shigeru Matsuoka, Shigeharu Harada, Kiyoshi Kita, Daniel Ken Inaoka and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kazuaki MatobaDepartment of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan.
Takeshi NaraDepartment of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, 113-8421, Japan.
Takashi AokiDepartment of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo, 113-8421, Japan.
Teruki HonmaSystems and Structural Biology Center, RIKEN, Tsurumi, Yokohama, 230-0045, Japan.
Akiko TanakaSystems and Structural Biology Center, RIKEN, Tsurumi, Yokohama, 230-0045, Japan.
Masayuki InoueGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Shigeru MatsuokaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113-0033, Japan.
Shigeharu HaradaDepartment of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan.
Kiyoshi KitaDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
Daniel Ken InaokaDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
Emmanuel Oluwadare BalogunDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan. eobalogun@abu.edu.ng.
Tomoo ShibaDepartment of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto, 606-8585, Japan. tshiba@kit.ac.jp.

Funding

Multi-target approach to rational design of novel therapeutics for human African trypanosomiasisK43TW012015 · FIC · AHMADU BELLO UNIVERSITY · PI BALOGUN, EMMANUEL OLUWADARE · 2021 to 2025
$577k
AMED/JICA, SATREPS 1400738FIC NIH HHS K43 TW012015Fogarty International Center of the National Institutes of Health K43TW012015Research Program on Emerging and Re-emerging Infectious Diseases 25wm0125011
6 · The paper itself

Abstract

Aspartate transcarbamoylase (ATCase) catalyzes the second step of the de novo pyrimidine biosynthetic pathway and produces N-carbamoyl-L-aspartate (CA) and inorganic phosphate (P

Indexed as

Aspartate CarbamoyltransferaseTrypanosoma cruziAspartic AcidCarbamyl PhosphateCrystallography, X-RayModels, MolecularProtein ConformationAspartate CarbamoyltransferaseAspartic AcidCarbamyl Phosphate

Identifiers

PMID41927689
PMCPMC13195161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.