Evidence map›Paper›PMID 41927564›Full record

ArticleNature communications2026

Targeting REV-ERBα/BNIP3 axis attenuates pulmonary arterial hypertension by repressing mitophagy in mice.

Lejia Qiu, Tingting Lu, Jiayang Zhang, Min Liu, Hui Wang, Wenyu Li, Changxiao Ma, Shuyao Li, Baoyin Ren, Qiong Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lejia QiuWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Tingting LuWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Jiayang ZhangCollege of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Min LiuAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
Hui WangAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
Wenyu LiWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Changxiao MaWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Shuyao LiWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Baoyin RenWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Qiong WangWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Fenling FanDepartment of Cardiovascular Medicine, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Hu XuWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Feng ZhengWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.
Youfei GuanAdvanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
Xiaoyan ZhangWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China.ORCID http://orcid.org/0000-0002-4060-2423
Guangrui YangCollege of Basic Medical Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China. yanggr@sumhs.edu.cn.ORCID http://orcid.org/0000-0002-8310-8257
Lihong ChenWuHu Hospital & Health Science Center, East China Normal University, Shanghai, China. lhchen@hsc.ecnu.edu.cn.ORCID http://orcid.org/0000-0001-6370-1865

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32071157National Natural Science Foundation of China (National Science Foundation of China) 32571348
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a life-threatening metabolic disorder. Nuclear receptors REV-ERBα and REV-ERBβ are established regulators of circadian rhythm and metabolic homeostasis, however their roles in PAH remain unclear. Using Rev-erbα

Indexed as

Membrane ProteinsMitochondrial ProteinsMitophagyNuclear Receptor Subfamily 1, Group D, Member 1Pulmonary Arterial HypertensionAnimalsDisease Models, AnimalHypoxiaMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMuscle, Smooth, VascularMyocytes, Smooth MusclePulmonary ArteryMembrane ProteinsMitochondrial ProteinsNr1d1 protein, mouseNr1d2 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1PyrrolidinesReceptors, Cytoplasmic and NuclearRepressor Proteins

Identifiers

PMID41927564
PMCPMC13219654

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.